Erectile dysfunction can occur in any man, regardless of his age and lifestyle. Problems can appear even at 20-30 as well as in men who are over 50. However, all of these age groups have different causes of erectile dysfunction, and the disease itself can manifest in different ways. In this article, we will help you to find out which drugs are better to use in certain situations.
When Do Medications Required?
Sometimes the erection weakens once and is quickly restored – in this case, the cause of the erectile dysfunction is not terrible (for example, the patient is tired after work, or quarreled with his wife, experienced stress). To improve the erection, do not run to a specialist – just calm down, relax or use a mild stimulant.
In other cases, erectile dysfunction can occur regularly. It is very important to establish the cause – if this is a disease, then you must immediately start treatment. It can be a serious disease – diabetes, CNS diseases, prostate inflammation, adenoma or swelling in the prostate, testis, hormonal failures, trauma to the urogenital system and other health problems.
Success in improving an erection depends on the neglect of the pathology that caused erectile dysfunction. If the disease was identified in the initial stages, then the treatment will be relatively simple, and the erectile ability will return quickly. If the disease is at the latest stage and lasts for long, then it is necessary to treat ED for about 6-10 months. Let’s have a look at the most effective pills for ED.
Viagra (Sildenafil) is a potent selective inhibitor of cyclo-guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE-5). Mechanism of action: the implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in cavernous bodies during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of the smooth muscle tissue of the cavernous bodies and an increase in blood flow.
Sildenafil does not have a direct relaxing effect on an isolated cavernous human body, but enhances the effect of nitric oxide (NO) by inhibiting PDE-5, which is responsible for the degradation of cGMP. The efficacy and safety of sildenafil was evaluated in 21 randomized, double-blind, placebo-controlled trials lasting up to 6 months in 3000 patients aged 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed).
The effectiveness of the drug was assessed globally using the diary of erections, the international index of erectile function (a validated questionnaire on the status of sexual function), and a partner survey. To diagnose erectile dysfunction, determine their possible causes and choose an adequate treatment, you must collect a complete medical history and conduct a thorough physical examination.
Cialis is based on Tadalafil. The effect of tadalafil on PDE5 is more active than on other phosphodiesterases. Tadalafil is 10,000 times more active against PDE5 than with PDE1, PDE2, PDE4, PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Tadalafil 10,000 times more actively blocks PDE5 than PDE3 – an enzyme that is found in the heart and blood vessels. This selectivity for PDE5 in comparison with PDE3 is important, since PDE3 is an enzyme involved in contracting the heart muscle. In addition, tadalafil is approximately 700 times more active with respect to PDE5 than with respect to PDE6, found in the retina and is responsible for photo transmission.
Tadalafil also exhibits an effect that is 9000 times more potent with respect to PDE5 than its effect on PDE8, at 9, 10 and 14 times more potent for PDE5 than PDE11. The distribution in tissues and the physiological effects of the inhibition of PDE8-PDE11 have not yet been elucidated. Tadalafil improves the erection and the possibility of a successful sexual intercourse. The drug acts for 36 hours. The effect manifests itself already 16 minutes after taking the drug in the presence of sexual arousal. Tadalafil does not cause changes in color recognition (blue / green), which is explained by its low affinity for PDE6. In addition, there is no evidence of tadalafil’s influence on visual acuity, electroretinogram, intraocular pressure and pupil size.
The recommended maximum dose of Cialis is 20 mg. The maximum recommended frequency of reception is 1 time / day. Patients can attempt to have intercourse at any time within 36 hours after taking the drug in order to establish the optimal response time for taking the drug.
The main active ingredient of such tablets is Vardenafil. It affects the parts of the brain that are responsible for sexual arousal. As a result, blood circulation in the cavernous bodies of the penis increases, which leads to an erection during stimulation of the penis or other erogenous zones.
The principle of Levitra is simple: the drug blocks a chemical component that prevents the blood from entering the penis, which causes the brain to give certain signals, which activates the release of a chemical responsible for the normalization of blood circulation in intimate organs.
The period of action of the drug is approximately 5-6 hours, the exact time depends on the individual characteristics of the organism. Of course, this does not mean that the erection will not stop for several hours: you can make sexual intercourse at a convenient time. Levitra starts to act about 15-25 minutes after taking the pill.
Silagra 100 mg (active ingredient – Sildenafil citrate 100 mg) – the newest drug for the treatment of male impotence. The drug is similar in effect to Viagra. Silagra is popular among men due to the low price and almost complete absence of side effects. Medical preparation Silagra 100 mg is one of the most modern means for improving male potency. In fact, this is an analogue of Viagra, however it is safer and not so expensive.
In the composition of the preparation Silagra 100, the main component is also Sildenafil, which acts on the blood vessels of the genital organ, so that blood circulation improves significantly and the man feels the flow of energy. The duration of action is not more than 4 hours. It is recommended to take the drug half an hour before sex. In no case should you use more than 100 mg for one day. And the most minimal dose is 25 mg. The optimal dosage is 50 mg.
Kamagra is a drug for the treatment of erectile dysfunction. Sildenafil citrate is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.
Nitric oxide activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate (cGMP), relaxation of smooth muscles of the cavernous body, and increased blood flow in the penis. The dosage is the same as the brand Viagra has- not more than 100 mg per day.
Injection method of treatment of erectile dysfunction
By means of intracavernous injection, prostaglandins are administered. They have an expanding effect that extends to the muscular cells of the cavernous bodies and to the blood vessels. Due to this, there is an increase in blood flow and an improvement in erectile function. The high effectiveness of intracavernous injections makes them one of the most popular ways to treat impotence.
- The advantages of this therapy are increased male libido;
- prolongation of an erection;
- increase in muscle mass; restoration of blood flow in the penis;
- increase self-esteem.
Stimulation of nerve endings, permeating the reproductive organ, has a positive effect on the condition of cavernous bodies. Intracavernous administration will increase the functionality of the penis and delay surgical intervention. Unfortunately, the use of this technique does not exclude a contraindications and doctor consultation.